3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride → HCID 59683533, compound

HRID 2389628Notes

Reaction equation

HRID 2389628 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16](O)([OH:21])[C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)=[CH:6][C:5]=1[CH2:23][NH:24][CH:25]1[CH2:30][CH2:29][CH:28]([N:31]([CH3:39])[C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35])[CH2:27][CH2:26]1)[CH3:2].[Cl:40][C:41]1[C:42]2[C:52]([F:53])=[CH:51][CH:50]=[C:49]([F:54])[C:43]=2[S:44][C:45]=1[C:46](Cl)=[O:47]>>[Cl:40][C:41]1[C:42]2[C:52]([F:53])=[CH:51][CH:50]=[C:49]([F:54])[C:43]=2[S:44][C:45]=1[C:46]([N:24]([CH2:23][C:5]1[CH:6]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16](=[O:21])[C:17]([F:20])([F:18])[F:19])=[CH:12][CH:11]=2)[CH:8]=[CH:9][C:4]=1[O:3][CH2:1][CH3:2])[CH:25]1[CH2:30][CH2:29][CH:28]([N:31]([CH3:39])[C:32](=[O:38])[O:33][C:34]([CH3:35])([CH3:37])[CH3:36])[CH2:27][CH2:26]1)=[O:47]

Participants

3

Reactant 2

HCID 219384153-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chlorideHCID 59683601HCID 59683601, compound

Product 1

HCID 59683533HCID 59683533, compound

Procedure

Biaryl amine 119 (487 mg, 0.88 mmol) is treated with acid chloride 8 (235 mg, 0.88 mmol) using Method D to give the title compound.

Sources & evidence

ORD record
ord-be110371faf84eb6a1df32733f8d09b0
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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