3-Chloro-4-fluoro-1-benzothiophene-2-carbonyl chloride → tert-Butyl (4-{(3-chloro-4-fluoro-benzo[b]thiophene-2-carbonyl)-[4'-(formyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate

Participants

Role	Name	HCID	Charge
Reactant	3-Chloro-4-fluoro-1-benzothiophene-2-carbonyl chloride	HCID 12594645	—
Reactant	tert-Butyl (4-{[4'-(formyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate	HCID 25208192	—
Product	tert-Butyl (4-{(3-chloro-4-fluoro-benzo[b]thiophene-2-carbonyl)-[4'-(formyl-methyl-amino)-4-methoxy-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamate	HCID 59683580	—

Biaryl amine 52 (200 mg, 0.42 mmol) is treated with acid chloride 6 (120 mg, 0.49 mmol) using Method D to afford the title compound.