HCID 58482986, compound → HCID 58483020, compound

Participants

Reaction Steps

To a solution of 5-[2-(benzyloxy)ethyl]-1-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide (220 mg, 0.38 mmol) in MeOH (3 mL), Pd(OH)2—C (20 mg) was added and stirred overnight under H2 atmosphere at room temperature. After the reaction, Pd(OH)2—C was filtered off and the solvent was evaporated. The residue was purified over silica gel (AcOEt/n-hexane, 9:1 v/v) to give the atropisomeric mixture of the title compound (170 mg, 92%) as a foam.

Provenance & Evidence