HRID2389640

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21938415

3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride

C9H2Cl2F2OS

结构：COc1ccc(-c2ccc(N)nc2)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683549

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccc(N)nc2)cc1CN(C(=O)c1sc2c(F)ccc(F)c2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683462

未命名化合物

PROCEDURE

实验过程

Crude biaryl amine 142 (300 mg, 0.68 mmol) is treated with acid chloride 8 (182 mg, 0.68 mmol) using Method D to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79399900346b4996a0f8799c9f6e0f04
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([O:31][CH3:32])=[C:12]([CH:30]=2)[CH2:13][NH:14][CH:15]2[CH2:20][CH2:19][CH:18]([N:21]([CH3:29])[C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH2:17][CH2:16]2)=[CH:4][CH:3]=1.[Cl:33][C:34]1[C:35]2[C:45]([F:46])=[CH:44][CH:43]=[C:42]([F:47])[C:36]=2[S:37][C:38]=1[C:39](Cl)=[O:40]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([O:31][CH3:32])=[C:12]([CH:30]=2)[CH2:13][N:14]([C:39]([C:38]2[S:37][C:36]3[C:42]([F:47])=[CH:43][CH:44]=[C:45]([F:46])[C:35]=3[C:34]=2[Cl:33])=[O:40])[CH:15]2[CH2:16][CH2:17][CH:18]([N:21]([CH3:29])[C:22](=[O:28])[O:23][C:24]([CH3:26])([CH3:27])[CH3:25])[CH2:19][CH2:20]2)=[CH:4][CH:3]=1