Acetyl chloride → HCID 59683512, compound

Participants

Reaction Steps

Acetyl chloride (5 mL) is added to anhydrous MeOH (10 mL) at 0° C. tert-Butyl carbamate 148 (247 mg, 0.35 mmol) is then treated with this solution and stirred 2 h. On removal of the solvents in vacuo, the reaction mixture is dissolved in DCM (25 mL) and extracted into 2 M HCl (4×10 mL). The combined HCl phases are washed with DCM (2×20 mL) then taken to pH 9 by careful addition of solid NaHCO3. The resultant aqueous suspension is then extracted into DCM (3×20 mL), the combined DCM phases dried (Na2SO4) and reduced in vacuo to afford the title compound.

Provenance & Evidence