4-Bromopyridinium chloride → 2-Methoxy-5-(pyridin-4-yl)benzaldehyde

HRID 2389660Notes

Reaction equation

HRID 2389660 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])=[O:2].Cl.Br[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1>>[CH3:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[CH:4][C:3]=1[CH:1]=[O:2]

Participants

3

Reactant 2

HCID 881004-Bromopyridinium chlorideHCID 2759225(3-Formyl-4-methoxyphenyl)boronic acid

Product 1

HCID 105605352-Methoxy-5-(pyridin-4-yl)benzaldehyde

Procedure

3-formyl-4-methoxybenzeneboronic acid (393 mg, 2.19 mmol) is coupled to 4-bromopyridine hydrochloride (400 mg, 2.19 mmol) using Method A to give the title compound.

Sources & evidence

ORD record
ord-ee815974dbd346c982dd32786d9d6b1d
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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