HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-((methylsulfonyl)methyl)benzene → tert-Butyl{4-[(4'-methanesulfonylmethyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-((methylsulfonyl)methyl)benzene | HCID 2761415 | — |
| Reactant | 3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid | HCID 25208191 | — |
| Product | tert-Butyl{4-[(4'-methanesulfonylmethyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate | HCID 59683471 | — |
Reaction Steps
Boronic acid 4 (200 mg, 0.51 mmol) is coupled to aryl bromide 197 (127 mg, 0.51 mmol) using Method A. On filtration of the cooled reaction mixture through celite and removal of the solvents in vacuo, the crude residue obtained is used in the next synthetic step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-1d10fab51f554a0c97d1b6b2915508bc |
| Source note | uspto-grants-2012_09 |