N-(4-Bromophenyl)methanesulfonamide → HCID 59683529, compound

HRID 2389667Notes

Reaction equation

HRID 2389667 reaction equation
[C:1]([N:8]([CH3:28])[CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][CH2:16][C:17]2[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:22]=2[O:23][CH3:24])[CH2:11][CH2:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Br[C:30]1[CH:35]=[CH:34][C:33]([NH:36][S:37]([CH3:40])(=[O:39])=[O:38])=[CH:32][CH:31]=1>>[CH3:40][S:37]([NH:36][C:33]1[CH:32]=[CH:31][C:30]([C:19]2[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:17]([CH2:16][NH:15][CH:12]3[CH2:13][CH2:14][CH:9]([N:8]([CH3:28])[C:1](=[O:2])[O:3][C:4]([CH3:7])([CH3:6])[CH3:5])[CH2:10][CH2:11]3)[CH:18]=2)=[CH:35][CH:34]=1)(=[O:39])=[O:38]

Participants

3

Reactant 2

HCID 706841N-(4-Bromophenyl)methanesulfonamideHCID 252081913-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid

Product 1

HCID 59683529HCID 59683529, compound

Procedure

Boronic acid 4 (200 mg, 0.51 mmol) is coupled to aryl bromide 201 (134 mg, 0.54 mmol) using Method A to give the title compound.

Sources & evidence

ORD record
ord-1fa268bf094145aa94b8595b1fe3ac15
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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