HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromothioanisole → HCID 59683470, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromothioanisole | HCID 2735627 | — |
| Reactant | 3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride | HCID 21938415 | — |
| Reactant | 3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzene boronic acid | HCID 25208191 | — |
| Product | HCID 59683470 | HCID 59683470 | — |
Reaction Steps
Boronic acid 4 (300 mg, 0.77 mmol) is coupled to 3-bromothioanisole (156 mg, 0.77 mmol) using Method A. On filtration of the cooled reaction mixture through celite and removal of the solvents in vacuo, the crude biaryl amine is treated with acid chloride 8 (246 mg, 0.92 mmol) using Method D to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-be8cc99edad94d27967d99ca95a51d4a |
| Source note | uspto-grants-2012_09 |