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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389677Generated: October 30, 2026

3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride → HCID 25025627, compound

https://huagongshe.com/reaction/2389677

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chlorideHCID 21938415—
ReactantHCID 59683597HCID 59683597—
ProductHCID 25025627HCID 25025627—

Reaction Steps

Following the synthetic protocol described in Method D′; 3-Chloro-4,7-difluoro-benzo[b]thiophene-2-carboxylic acid [5-(6-fluoro-pyridin-3-yl)-2-methoxy-benzyl]-(4-methylamino-cyclohexyl)-amide is prepared starting from {4-[5-(6-Fluoro-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester and 3-Chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl chloride. The desired product is isolated in 57%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273747B2
Source datasetuspto-grants-2012_09
ORD IDord-c76e05789b60450f8e1a0e111d94f247
Source noteuspto-grants-2012_09