HRID2389688

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21938415

3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride

C9H2Cl2F2OS

结构：COc1ccc(Br)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683581

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Br)cc1CN(C(=O)c1sc2c(F)ccc(F)c2c1Cl)C1CCC(N(C)C(=O)OC(C)(C)C)CC1

HCID59683556

未命名化合物

PROCEDURE

实验过程

Biaryl amine 219 (0.50 g, 1.17 mmol) is treated with acid chloride 8 (344 mg, 1.29 mmol) using Method D to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e80bf4933b634d34ac0d4e5084dd7309
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([CH:24]=1)[CH2:7][NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:11][CH2:10]1.[Cl:27][C:28]1[C:29]2[C:39]([F:40])=[CH:38][CH:37]=[C:36]([F:41])[C:30]=2[S:31][C:32]=1[C:33](Cl)=[O:34]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([CH:24]=1)[CH2:7][N:8]([C:33]([C:32]1[S:31][C:30]2[C:36]([F:41])=[CH:37][CH:38]=[C:39]([F:40])[C:29]=2[C:28]=1[Cl:27])=[O:34])[CH:9]1[CH2:10][CH2:11][CH:12]([N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:21])[CH3:19])[CH2:13][CH2:14]1