HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Ethylsulphonyl)benzeneboronic acid → tert-Butyl {4-[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4'-ethanesulfonyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Ethylsulphonyl)benzeneboronic acid | HCID 2773420 | — |
| Reactant | tert-Butyl {4-[(5-bromo-2-methoxy-benzyl)-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamate | HCID 59683556 | — |
| Product | tert-Butyl {4-[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4'-ethanesulfonyl-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate | HCID 59683486 | — |
Reaction Steps
Aryl bromide 220 (200 mg, 0.30 mmol) is coupled to 4-(ethanesulfonyl)-benzene boronic acid (65 mg, 0.30 mmol) using Method A to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-cc16122cbffd402f9d6795b4c693b465 |
| Source note | uspto-grants-2012_09 |