3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride → HCID 59683586, compound

HRID 2389692Notes

Reaction equation

HRID 2389692 reaction equation
[CH3:1][N:2]([CH:10]1[CH2:15][CH2:14][CH:13]([NH:16][CH2:17][C:18]2[CH:23]=[C:22]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)[CH:21]=[CH:20][C:19]=2[CH3:30])[CH2:12][CH2:11]1)[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[Cl:31][C:32]1[C:33]2[C:43]([F:44])=[CH:42][CH:41]=[C:40]([F:45])[C:34]=2[S:35][C:36]=1[C:37](Cl)=[O:38]>>[Cl:31][C:32]1[C:33]2[C:43]([F:44])=[CH:42][CH:41]=[C:40]([F:45])[C:34]=2[S:35][C:36]=1[C:37]([N:16]([CH2:17][C:18]1[CH:23]=[C:22]([C:24]2[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=2)[CH:21]=[CH:20][C:19]=1[CH3:30])[CH:13]1[CH2:14][CH2:15][CH:10]([N:2]([CH3:1])[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6])[CH2:11][CH2:12]1)=[O:38]

Participants

3

Reactant 2

HCID 219384153-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chlorideHCID 59683602HCID 59683602, compound

Product 1

HCID 59683586HCID 59683586, compound

Procedure

Crude biaryl amine 232 (36 mg) is treated with acid chloride 8 (29 mg, 0.11 mmol) using Method D to afford the title compound.

Sources & evidence

ORD record
ord-190c7035b32045f4a5e61fdbdc86f792
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

Loading…