(Pyridin-4-yl)boronic acid → 2-Ethyl-5-pyridin-4-yl-benzaldehyde

HRID 2389697Notes

Reaction equation

HRID 2389697 reaction equation
[N:1]1[CH:6]=[CH:5][C:4](B(O)O)=[CH:3][CH:2]=1.Br[C:11]1[CH:12]=[CH:13][C:14]([CH2:19][CH3:20])=[C:15]([CH:18]=1)[CH:16]=[O:17]>>[CH2:19]([C:14]1[CH:13]=[CH:12][C:11]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)=[CH:18][C:15]=1[CH:16]=[O:17])[CH3:20]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 547723895-Bromo-2-ethylbenzaldehyde

Product 1

HCID 596835832-Ethyl-5-pyridin-4-yl-benzaldehyde

Procedure

Pyridine-4-boronic acid (75 mg, 0.52 mmol) is coupled to aryl bromide 235 (111 mg, 0.52 mmol) using Method A to give the title compound.

Sources & evidence

ORD record
ord-3f63b2882cbd4f309da33c064cc40567
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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