2-Pyridinamine, 5-bromo-6-methyl- → 3-Chloro-benzo[b]thiophene-2-carboxylic acid [2-ethoxy-5-(6-amino-pyridin-3-yl)-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2-Pyridinamine, 5-bromo-6-methyl-	HCID 170678	—
Reactant	3-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzene boronic acid	HCID 59683494	—
Product	3-Chloro-benzo[b]thiophene-2-carboxylic acid [2-ethoxy-5-(6-amino-pyridin-3-yl)-benzyl]-(4-methylamino-cyclohexyl)-amide dihydrochloride	HCID 68314530	—

Reaction Steps

The title compound was prepared from boronic acid (12) (25 mg, 42 μmol) and 6-amino-3-bromo-2-methylpyridine (6.5 mg, 40 μmol) in accordance with Method L2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273747B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-71a8532511d54aafb532c7654ffee205
Source note	uspto-grants-2012_09