5-Bromo-N-methylpyridin-2-amine → HCID 68313981, compound

HRID 2389701Notes

Reaction equation

HRID 2389701 reaction equation
C([N:8]([CH3:40])[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:28][C:29]2[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=2[O:35][CH3:36])[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.Br[C:42]1[CH:43]=[CH:44][C:45]([NH:48][CH3:49])=[N:46][CH:47]=1>>[ClH:27].[ClH:27].[CH3:36][O:35][C:34]1[CH:33]=[CH:32][C:31]([C:42]2[CH:47]=[N:46][C:45]([NH:48][CH3:49])=[CH:44][CH:43]=2)=[CH:30][C:29]=1[CH2:28][N:15]([CH:12]1[CH2:13][CH2:14][CH:9]([NH:8][CH3:40])[CH2:10][CH2:11]1)[C:16]([C:18]1[S:22][C:21]2[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=2[C:19]=1[Cl:27])=[O:17]

Participants

3

Reactant 2

HCID 156456635-Bromo-N-methylpyridin-2-amineHCID 596836463-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chlorobenzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzene boronic acid

Product 1

HCID 68313981HCID 68313981, compound

Procedure

The title compound was prepared from boronic acid (5) (25 mg, 43 μmol) and 5-bromo-2-methylaminopyridine (6.6 mg, 41 μmol) in accordance with Method L2.

Sources & evidence

ORD record
ord-0d0b9b37853940c8b8d94ac4a5d97b3f
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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