2-Pyridinamine, 5-bromo-6-methyl- → HCID 68313955, compound

HRID 2389702Notes

Reaction equation

HRID 2389702 reaction equation
[C:1]([N:8](C)[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:28][C:29]2[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=2[O:35][CH3:36])[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.[NH2:41][C:42]1[N:47]=[C:46]([CH3:48])[C:45](Br)=[CH:44][CH:43]=1>>[ClH:27].[ClH:27].[NH2:41][C:42]1[N:47]=[C:46]([CH3:48])[C:45]([C:31]2[CH:32]=[CH:33][C:34]([O:35][CH3:36])=[C:29]([CH:30]=2)[CH2:28][N:15]([CH:12]2[CH2:13][CH2:14][CH:9]([NH:8][CH3:1])[CH2:10][CH2:11]2)[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])=[CH:44][CH:43]=1

Participants

3

Reactant 2

HCID 1706782-Pyridinamine, 5-bromo-6-methyl-HCID 596836463-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chlorobenzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzene boronic acid

Product 1

HCID 68313955HCID 68313955, compound

Procedure

The title compound was prepared from boronic acid (5) (25 mg, 43 μmol) and 6-amino-3-bromo-2-methylpyridine (6.6 mg, 41 μmol) in accordance with Method L2.

Sources & evidence

ORD record
ord-d710b9ec41144b519aba647b2cf8c8f3
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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