5-Bromo-N-methylpyrimidin-2-amine → HCID 68314501, compound

HRID 2389705Notes

Reaction equation

HRID 2389705 reaction equation
[C:1]([N:8](C)[CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([CH2:28][C:29]2[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][C:34]=2[O:35][CH2:36][CH3:37])[C:16]([C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[Cl:27])=[O:17])[CH2:11][CH2:10]1)(OC(C)(C)C)=O.Br[C:43]1[CH:44]=[N:45][C:46]([NH:49][CH3:50])=[N:47][CH:48]=1>>[ClH:27].[ClH:27].[CH2:36]([O:35][C:34]1[CH:33]=[CH:32][C:31]([C:43]2[CH:44]=[N:45][C:46]([NH:49][CH3:50])=[N:47][CH:48]=2)=[CH:30][C:29]=1[CH2:28][N:15]([CH:12]1[CH2:11][CH2:10][CH:9]([NH:8][CH3:1])[CH2:14][CH2:13]1)[C:16]([C:18]1[S:22][C:21]2[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=2[C:19]=1[Cl:27])=[O:17])[CH3:37]

Participants

3

Reactant 2

HCID 130981845-Bromo-N-methylpyrimidin-2-amineHCID 596834943-{[[4-(BOC-methyl-amino)-cyclohexyl]-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzene boronic acid

Product 1

HCID 68314501HCID 68314501, compound

Procedure

The title compound was prepared from boronic acid (12) (25 mg, 42 μmol) and 5-bromo-2-methylaminopyrimidine (6.5 mg, 41 μmol) in accordance with Method L2.

Sources & evidence

ORD record
ord-8fe2dc3761a54d3385762c18634fefc8
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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