m-Chloroperbenzoic acid → HCID 59766902, compound

Participants

Reaction Steps

To a stirred suspension of thioanisole (286) (75 mg, 0.11 mmol) and NaHCO3 (46 mg, 0.55 mmol) in DCM (2 ml) at 0° C. was added dropwise a solution of m-chloroperbenzoic acid (34 mg, 0.2 mmol) in DCM (1 ml) over 2 min. After 2 h, LCMS showed a mixture of sulphoxide and sulphone. The reaction was diluted with aqueous Na2SO3 and extracted with DCM. The combined organic layers were dried (Na2SO4), filtered and reduced in vacuo before purification by chromatography with EtOAc/heptane to give the title compound.

Provenance & Evidence