Benzyl Alcohol → HCID 178454052, compound

Participants

Reaction Conditions

Reaction Steps

To BOC amino acid (293) (255 mg, 1.05 mmol) and triethylamine (0.58 mL, 4.2 mmol) in toluene (3 mL) at 45° C. was added dropwise diphenyl phosphoryl azide (0.23 ml, 1.15 mmol). Benzyl alcohol (0.16 mL, 1.58 mmol) was then added and the reaction heated at 55° C. for 4 h. The reaction was cooled to RT then washed with H2O, 1M KHSO4, and saturated sodium bicarbonate solution. The organic layer was dried (Na2SO4), filtered and reduced in vacuo to give the title compound.

Provenance & Evidence