4-Bromopyridinium chloride → 2-Methoxy-5-(pyridin-4-yl)benzaldehyde
Reaction equation
[CH:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])=[O:2].Cl.Br[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1>>[CH3:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[CH:4][C:3]=1[CH:1]=[O:2]Participants
3
Procedure
3-Formyl-4-methoxyphenyl boronic acid (393 mg, 2.19 mmol) and 4-bromopyridine hydrochloride (400 mg, 2.19 mmol) were coupled using Method A to give the title compound.
Sources & evidence
- ORD record
- ord-5e94360475534dc885857a0bf9c1c8df
- Source dataset
- uspto-grants-2012_09
- Patent number
- US08273747B2
Reaction notes
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