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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389719Generated: November 1, 2026

3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride → {4-[(3-Chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/2389719

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chlorideHCID 21938415—
Reactant[4-(2-Methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl esterHCID 59683557—
Product{4-[(3-Chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-carbamic acid tert-butyl esterHCID 59683606—

Reaction Steps

Amine (297) (156 mg, 0.38 mmol) was reacted with acid chloride 8 (110 mg, 0.42 mmol) using Method D to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273747B2
Source datasetuspto-grants-2012_09
ORD IDord-00e9f9ded6c14d1db8741184d44755b3
Source noteuspto-grants-2012_09