HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride → {4-[(3-Chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride | HCID 21938415 | — |
| Reactant | [4-(2-Methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester | HCID 59683557 | — |
| Product | {4-[(3-Chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-carbamic acid tert-butyl ester | HCID 59683606 | — |
Reaction Steps
Amine (297) (156 mg, 0.38 mmol) was reacted with acid chloride 8 (110 mg, 0.42 mmol) using Method D to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-00e9f9ded6c14d1db8741184d44755b3 |
| Source note | uspto-grants-2012_09 |