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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389721Generated: October 26, 2026

N-(4-Bromophenyl)-N-methyl-formamide → (4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/2389721

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(4-Bromophenyl)-N-methyl-formamideHCID 15004464—
Reactant3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-fluoro-benzene boronic acidHCID 59766904—
Product(4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl esterHCID 59766952—

Reaction Steps

The title compound was prepared from boronic acid (247) (300 mg, 0.79 mmol) and aryl bromide (51) (200 mg, 0.95 mmol) in accordance with Method B.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273747B2
Source datasetuspto-grants-2012_09
ORD IDord-ec7d72cd24764cf09ddbba8bb9ded881
Source noteuspto-grants-2012_09