HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Bromophenyl)-N-methyl-formamide → (4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Bromophenyl)-N-methyl-formamide | HCID 15004464 | — |
| Reactant | 3-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-fluoro-benzene boronic acid | HCID 59766904 | — |
| Product | (4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester | HCID 59766952 | — |
Reaction Steps
The title compound was prepared from boronic acid (247) (300 mg, 0.79 mmol) and aryl bromide (51) (200 mg, 0.95 mmol) in accordance with Method B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-ec7d72cd24764cf09ddbba8bb9ded881 |
| Source note | uspto-grants-2012_09 |