HRID2389722

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID519898

3-Chlorobenzo[b]thiophene-2-carbonyl chloride

C9H4Cl2OS

结构：CN(C=O)c1ccc(-c2ccc(F)c(CNC3CCC(N(C)C(=O)OC(C)(C)C)CC3)c2)cc1

HCID59766952

未命名化合物

PRODUCTS

生成物

结构：CN(C=O)c1ccc(-c2ccc(F)c(CN(C(=O)c3sc4ccccc4c3Cl)C3CCC(N(C)C(=O)OC(C)(C)C)CC3)c2)cc1

HCID59766950

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from amine (261) (270 mg, 0.58 mmol) and 3-chlorobenzo[b]thiophene-2-carbonyl chloride (150 mg, 0.63 mmol) following Method D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a93d9e5f3a87421ea449aaa8f996c768
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([O:5][C:6](=[O:34])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][CH2:16][C:17]2[CH:18]=[C:19]([C:24]3[CH:29]=[CH:28][C:27]([N:30]([CH:32]=[O:33])[CH3:31])=[CH:26][CH:25]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[Cl:35][C:36]1[C:37]2[CH:47]=[CH:46][CH:45]=[CH:44][C:38]=2[S:39][C:40]=1[C:41](Cl)=[O:42]>>[C:1]([O:5][C:6](=[O:34])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([C:41]([C:40]2[S:39][C:38]3[CH:44]=[CH:45][CH:46]=[CH:47][C:37]=3[C:36]=2[Cl:35])=[O:42])[CH2:16][C:17]2[CH:18]=[C:19]([C:24]3[CH:29]=[CH:28][C:27]([N:30]([CH:32]=[O:33])[CH3:31])=[CH:26][CH:25]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:2])[CH3:3]