3-Chlorobenzo(b)thiophene-2-carbonyl chloride → (4-{(3-Chloro-benzo[b]thiophene-2-carbonyl)-[4-fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

HRID 2389722Notes

Reaction equation

HRID 2389722 reaction equation
[C:1]([O:5][C:6](=[O:34])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][CH2:16][C:17]2[CH:18]=[C:19]([C:24]3[CH:29]=[CH:28][C:27]([N:30]([CH:32]=[O:33])[CH3:31])=[CH:26][CH:25]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[Cl:35][C:36]1[C:37]2[CH:47]=[CH:46][CH:45]=[CH:44][C:38]=2[S:39][C:40]=1[C:41](Cl)=[O:42]>>[C:1]([O:5][C:6](=[O:34])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([C:41]([C:40]2[S:39][C:38]3[CH:44]=[CH:45][CH:46]=[CH:47][C:37]=3[C:36]=2[Cl:35])=[O:42])[CH2:16][C:17]2[CH:18]=[C:19]([C:24]3[CH:29]=[CH:28][C:27]([N:30]([CH:32]=[O:33])[CH3:31])=[CH:26][CH:25]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 5198983-Chlorobenzo(b)thiophene-2-carbonyl chlorideHCID 59766952(4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

Product 1

HCID 59766950(4-{(3-Chloro-benzo[b]thiophene-2-carbonyl)-[4-fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from amine (261) (270 mg, 0.58 mmol) and 3-chlorobenzo[b]thiophene-2-carbonyl chloride (150 mg, 0.63 mmol) following Method D.

Sources & evidence

ORD record
ord-a93d9e5f3a87421ea449aaa8f996c768
Source dataset
uspto-grants-2012_09
Patent number
US08273747B2

Reaction notes

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