3-Chlorobenzo(b)thiophene-2-carbonyl chloride → (4-{(3-Chloro-benzo[b]thiophene-2-carbonyl)-[4-fluoro-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	3-Chlorobenzo(b)thiophene-2-carbonyl chloride	HCID 519898	—
Reactant	(4-{[4-Fluoro-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester	HCID 59766911	—
Product	(4-{(3-Chloro-benzo[b]thiophene-2-carbonyl)-[4-fluoro-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester	HCID 59766908	—

Reaction Steps

The title compound was prepared from amine (264) (220 mg, 0.43 mmol) and 3-chlorobenzo[b]thiophene-2-carbonyl chloride (110 mg, 0.48 mmol) following Method D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273747B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-cacc558a3d614a9aaa8bac82bfddf8da
Source note	uspto-grants-2012_09