Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-BOC-ethylenediamine | HCID 187201 | — |
| Reactant | HCID 59312932 | HCID 59312932 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 59312979 | HCID 59312979 | — |
Reaction Steps
3.0 g (10.05 mmol) of 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidine, 2.41 g (15.07 mmol) of N-Boc-ethylenediamine and 3.89 g (30.15 mmol) of diisopropylethylamine are dissolved in 50 ml of DMSO and heated at 120° C. for 16 h. Ethyl acetate and water are added, and the removed organic phase is washed twice more with water. The organic phase is dried with magnesium sulphate. Removal of the solvent results in 4.49 g (99% of theory) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273752B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-bab4e014337046daa45b89567d332ae6 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
