Potassium Hydroxide → HCID 178517803, compound

Participants

Reaction Steps

A solution of 73.25 g (366.87 mmol) of 7-chloro-5-(methylthio)imidazo[1,2-c]pyrimidine are dissolved in 732 ml of methanol, and 1275 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is heated under reflux for 3 h. After the reaction is complete, the methanol is removed in vacuo, the mixture is neutralized with half-concentrated hydrochloric acid, and the crystals which have separated out are filtered off with suction. They are washed with methanol and water and then dried under high vacuum. 40.0 g (64% of theory) of the product are obtained.

Provenance & Evidence