Dimethyl Sulfoxide → 5-Thiazolecarbonitrile, 4-amino-2-(methylsulfonyl)-

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Reaction Steps

2.7 g (15.77 mmol) of 4-amino-2-(methylthio)-1,3-thiazole-5-carbonitrile are dissolved in 200 ml of dichloromethane, and 11.97 g (34.7 mmol) of 3-chloroperbenzoic acid are added. The mixture is stirred at RT for 30 min and then 6 ml of DMSO are added, and then saturated aqueous sodium bicarbonate solution, and the mixture is extracted three times with dichloromethane. Drying of the organic phase over magnesium sulphate and removal of the solvent result in 2.22 g (46% of theory) of the product as an oil, which is employed without further purification.

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