反应详情

温度

105 °C

8 g (45.5 mmol) of 6-chloro-2-(methylthio)pyrimidine-4-amine and 5.78 g (45.55 mmol) of 1,3-dichloroacetone are dissolved in 53 ml of glacial acetic acid and heated at 105° C. for 16 h. After the reaction is complete, water is added and the precipitate is filtered off with suction. The crude product is further purified by silica gel chromatography. Drying under high vacuum results in 5.53 g (49% of theory) of product.

1. filtrationthe precipitate is filtered off with suction
2. customThe crude product is further purified by silica gel chromatography
3. customDrying under high vacuum
4. customresults in 5.53 g (49% of theory) of product