5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → Tert-butyl 3-(3-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonamido)phenyl)azetidine-1-carboxylate

Participants

Reaction Steps

Following the same procedure as described in Example 1.7, tert-butyl 3-(3-aminophenyl)azetidine-1-carboxylate (100 mg, 0.40 mmol) was coupled with 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (118 mg, 0.42 mmol) to give tert-butyl 3-(3-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonamido)phenyl)azetidine-1-carboxylate (140 mg, 71%).

Provenance & Evidence