Water → 6-({2-[(7-Chloro[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)amino]ethyl}amino)nicotinonitrile

Participants

Reaction Conditions

Reaction Steps

707 mg (3.20 mmol) of 5,7-dichloroimidazo[1,2-c]pyrimidine (Example 53A) are suspended in 25 ml of 2-propanol, and 1.35 g (3.52 mmol) of 6-[(2-aminoethyl)amino]nicotinonitrile trifluoroacetate (Example 13A) and 1.03 g (7.99 mmol) of DIPEA are added. The mixture is heated at 80° C. for 16 h. After this time, water is added and the precipitate which separates out is filtered off with suction. It is washed with a little 2-propanol/water, and the resulting solid is dried under high vacuum. 523 mg (50% of theory) of the product is obtained as a solid.

Provenance & Evidence