HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[(5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate | HCID 57911756 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride | HCID 67060338 | — |
Reaction Steps
2.24 g (3.4 mmol) of tert-butyl 3-[(5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate (Example 60A) are dissolved in 4.3 ml of a solution of hydrochloric acid in dioxane (4M) and stirred at RT for 3 h. After the reaction is complete, the solvent is completely removed. 1.74 g (90% of theory) of the product are obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273752B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-42f8032204094a3d846848a57597055a |
| Source note | uspto-grants-2012_09 |