Potassium Hydroxide → HCID 178437473, compound

HRID 2389787Notes

Reaction equation

HRID 2389787 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[N:10]=[C:11]([CH2:13][CH3:14])[N:12]=[C:4]2[CH:3]=1.[OH-:15].[K+]>>[Cl:1][C:2]1[N:7]=[C:6]([OH:15])[N:5]2[N:10]=[C:11]([CH2:13][CH3:14])[N:12]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 59313139HCID 59313139, compound

Product 1

HCID 178437473HCID 178437473, compound

Procedure

In analogy to Example 33A, 242 mg (99% of theory) of the product are obtained from 280 mg (1.22 mmol) of 7-chloro-2-ethyl-5-(methylsulphanyl)[1,2,4]triazolo[1,5-c]pyrimidine (Example 101A) by heating in methanolic potassium hydroxide solution.

Sources & evidence

ORD record
ord-624c758ad1de4eeab28cb9f3ca6330f9
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

Loading…