HCID 57470085, compound → HCID 68949242, compound

HRID 238980Notes

Reaction equation

HRID 238980 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH3:15])[CH2:9]2)=[CH:4][CH:3]=1.[F:16][CH:17]([F:30])[C@H:18]([C:20]1[CH:21]=[C:22]([S:26](Cl)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1)[CH3:19]>>[F:30][CH:17]([F:16])[C@H:18]([C:20]1[CH:21]=[C:22]([S:26]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C@@H:8]3[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH3:15])[CH2:9]3)=[CH:6][CH:7]=2)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1)[CH3:19]

Participants

3

Reactant 2

HCID 57470085HCID 57470085, compoundHCID 86636900HCID 86636900, compound

Product 1

HCID 68949242HCID 68949242, compound

Procedure

Following the same procedure as described in Example 1.7, (S)-3-(4-amino-phenyl)-1-propyl-pyrrolidine was coupled with (S)-3-(1,1-difluoropropan-2-yl)benzene-1-sulfonyl chloride to give the title compound.

Sources & evidence

ORD record
ord-732ccf4a6899469d82f06d1d44f3adc7
Source dataset
uspto-grants-2014_02
Patent number
US08642642B2

Reaction notes

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