Potassium Bicarbonate → N-[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Bicarbonate	HCID 516893	—
Reactant	2-Fluoro-5-(trifluoromethyl)pyridine	HCID 5463754	—
Reactant	N-[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]ethane-1,2-diamine trifluoroacetate	HCID 68710578	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Product	N-[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine	HCID 59312905	—

Reaction Conditions

Temperature	130 °C

Reaction Steps

50 mg (0.155 mmol) of the amine (Example 8A) are introduced into 3 ml of dry DMSO, 51.2 mg (0.31 mmol) of 2-fluoro-5-(trifluoromethyl)pyridine and 31.1 mg (0.31 mmol) of potassium bicarbonate are added, and the mixture is heated at 130° C. under argon for 16 h. Purification by preparative HPLC results in 22 mg (30% of theory) of the product as a solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273752B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-21fb31b5c77a4d818ab271f32e38d469
Source note	uspto-grants-2012_09