HCID 68953666, compound → HCID 68951105, compound

Participants

Reaction Steps

A solution of N-[3-((S)-1-benzyl-pyrrolidin-3-yl)-phenyl]-3-trifluoromethyl-benzene sulfonamid (620 mg, 1.34 mmol) (Example 65) in methanol (30 ml) was hydrogenated using the ThalesNano H-Cube® hydrogenation reactor employing a 10% palladium on charcoal catalyst cartridge. After concentration of the solution under reduced pressure, the crude product was purified with silica gel chromatography with ethyl acetate/methanol (1:1; 0:1) as eluent, yielding 328 mg of the purified product.

Provenance & Evidence