(2,4-Dichlorophenyl)boronic acid → HCID 59312930, compound

HRID 2389830Notes

Reaction equation

HRID 2389830 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][N:13]=2)[N:5]2[CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[N:22]=[C:4]2[CH:3]=1.[Cl:27][C:28]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:29]=1B(O)O>>[Cl:27][C:28]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:29]=1[C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][N:13]=2)[N:5]2[CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[N:22]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 2734659(2,4-Dichlorophenyl)boronic acidHCID 59313172HCID 59313172, compound

Product 1

HCID 59312930HCID 59312930, compound

Procedure

In analogy to the procedure described for Example 7, 11.4 mg (33% of theory) of the product are obtained as a solid starting from 29 mg (0.07 mmol) of 6-[(2-{[7-chloro-2-(trifluoromethyl)imidazo[1,2-c]pyrimidin-5-yl]amino}ethyl)amino]nicotinonitrile (Example 24A) by coupling with 13 mg (0.07 mmol) of (2,4-dichlorophenyl)boronic acid and subsequent purification by preparative HPLC.

Workup

  1. customare obtained as a solid

Sources & evidence

ORD record
ord-a7fc20af01194676b86369b11aee98f7
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

Loading…