HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-(tert-Butyl) 2-methyl (2S,4S)-4-phenylpyrrolidine-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(1,1-Dimethylethyl) (2S,4S)-4-phenyl-1,2-pyrrolidinedicarboxylate | HCID 2755978 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(tert-Butyl) 2-methyl (2S,4S)-4-phenylpyrrolidine-1,2-dicarboxylate | HCID 58002914 | — |
Reaction Steps
4.48 g of commercially available (2S,4S)-Boc-4-phenyl-pyrrolidine-2-carboxylic acid (15.37 mmol) were dissolved in 50 ml dimethylformamide. 2.59 g of potassium carbonate (18.76 mmol) and 2.66 g of methyl iodide (18.76 mmol) were added and the reaction was stirred for 48 h at room temperature. Standard work-up with ethyl acetate yielded 5.3 of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642642B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-2f492d0283a34cdeb60ddc7e892a1b07 |
| Source note | uspto-grants-2014_02 |