Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Furfural | HCID 7362 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Furanacrylic acid | HCID 643402 | 92% |
Reaction Steps
To a mixture of 2-furfural (500 g, 5.20 mol) and malonic acid (595 g, 5.72 mol) in pyridine (500 mL) was added piperidine (50 mL, 0.505 mol) at room temperature, and the mixture was stirred at 100° C. for 3 hr. The reaction solution was poured into water (1 L) and acidified with 6M hydrochloric acid. The resulting precipitate was collected by filtration to give the title compound (660 g, yield 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273761B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-f4f5782bb6ab4fe5b912f3315f5b6e9d |
|---|
| Source note | uspto-grants-2012_09 |
|---|
