Trimethylsilyl cyanide → (2-Phenyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)acetonitrile

Participants

Reaction Steps

To a solution of boron trifluoride diethyl ether complex (186 μL, 1.47 mmol) and trimethylsilyl cyanide (260 μL, 1.95 mmol) in dichloromethane (5 mL) was added a solution of (2-phenyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)methanol (130 mg, 0.488 mmol) in dichloromethane (10 mL) under ice-cooling and an argon atmosphere, and the mixture was stirred at room temperature for 1 hr. The reaction solution was diluted with saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90→40/60) to give the title compound (117 mg, yield 87%).

Provenance & Evidence