HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389917Generated: November 1, 2026
Dimethylamine → 2-((Dimethylamino)methyl)pyridin-3-ol
https://huagongshe.com/reaction/2389917
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 178418642 | HCID 178418642 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-((Dimethylamino)methyl)pyridin-3-ol | HCID 75108 | 65% |
Reaction Steps
To a solution of 4-hydroxypyridine (200 g, 2.10 mol) in water (500 mL) were added 50% aqueous dimethylamine (228 g) solution and 36% aqueous formalin (210 g) solution, and the mixture was stirred at 50° C. for 4 hr. The solvent was evaporated under reduced pressure, and the resulting crystals were collected by filtration to give the title compound (207 g, yield 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273761B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-cc77247631014b648cf12109add3ef49 |
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| Source note | uspto-grants-2012_09 |
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