HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (3-hydroxypyridin-2-yl)-N,N,N-trimethylmethanaminium iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-((Dimethylamino)methyl)pyridin-3-ol | HCID 75108 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (3-hydroxypyridin-2-yl)-N,N,N-trimethylmethanaminium iodide | HCID 2777200 | 92% |
Reaction Steps
To a solution of 2-[(dimethylamino)methyl]pyridin-3-ol (207 g, 1.37 mol) in acetone (2000 mL) was added dropwise iodomethane (778 g, 5.48 mol) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The resulting crystals were collected by filtration to give the title compound (369 g, yield 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273761B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-284a51039d62448186ac07493290f9ad |
| Source note | uspto-grants-2012_09 |