Phenacyl bromide → HCID 53310698, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,3-dihydrofuro[3,2-b]pyridin-5-amine (500 mg, 3.67 mmol) in ethanol (30 mL) were added 2-bromo-1-phenylethanone (730 mg, 3.67 mmol) and sodium carbonate (467 mg, 4.40 mmol), and the mixture was stirred at 80° C. for 14 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80→50/50) to give the title compound (136 mg, yield 16%).

Provenance & Evidence