HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 238993Generated: October 25, 2026
Hydrochloric Acid → Erlotinib Hydrochloride
https://huagongshe.com/reaction/238993
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| Solvent | Water | HCID 962 | — |
| Product | Erlotinib Hydrochloride | HCID 176871 | 88.8% |
Reaction Steps
5.0 g of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 75 ml water and 2.55 g of 3-aminophenyl acetylene was charged at 25-30° C. Further 1.0 ml 50% hydrochloric acid was added. The reaction mass was stirred at 25-30° C. for 2 hours. The solid obtained was filtered and washed with water. The product was dried at 40-45° C. to obtain 6.1 g of erlotinib hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08642758B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-aa922a47c9354357b4c91855f1dc64d8 |
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| Source note | uspto-grants-2014_02 |
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