Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86640910 | HCID 86640910 | — |
Reaction Steps
1.98 Kg of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 30 litres of water and 1.0 Kg of 3-aminophenyl acetylene was charged at 25-30° C. Further 0.4 litres sulphuric acid was added. The reaction mass was heated and stirred at 35-40° C. for 1 hour. The solid obtained was filtered and washed with ethyl acetate. The product was dried at 38-40° C. to obtain 2.65 Kg of erlotinib sulphate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08642758B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-b0880d8360fe4b8180b01270e6cc8e73 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
