HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239000Generated: October 30, 2026
p-Toluenesulfonic acid → HCID 86640911, compound
https://huagongshe.com/reaction/239000
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86640911 | HCID 86640911 | 223.7% |
Reaction Steps
5.0 g of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 75 ml ethyl acetate and 2.55 g of 3-aminophenyl acetylene was charged at 25-30° C. 0.9 g of p-toluyl sulphonic acid was added. The reaction mass was heated and stirred at 35-40° C. for 2 hours. The solid obtained was filtered and washed with ethyl acetate. The product was dried at 38-40° C. to obtain 6.6 g of erlotinib tosylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642758B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-d6ebd005b0a443bca6c51150bc84be22 |
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| Source note | uspto-grants-2014_02 |
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