Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59258822 | HCID 59258822 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178482358 | HCID 178482358 | — |
Reaction Steps
To 110 μL of 0.1 M solution of example 89 in DMF in a test tube (10×95 mm) was added 100 μL of 0.1 M solution of 3-aminopyrazole in DMF followed by 110 μL each of 0.1 M solution of HATU and triethylamine, respectively. The reaction mixture was stirred at 80° C. for 8 h. After the removal of the solvent in vacuo, the residue was reconstituted in 1.2 mL of DMSO and subjected to HPLC purification to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273755B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-dc7ec89d296641ccb4b40286e065ffe5 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
