Hydrochloric Acid → HCID 59323338, compound

Participants

Reaction Steps

10 mg of 2-(2-anilinoacetyl)-3-benzyl-1,2,3,4-tetrahydroisoquinoline was dissolved in 1 mL of THF, and 1.1 mg of LAH was added thereto under an argon atmosphere, followed by stirring under ice-cooling 2 hours. After completion of the reaction, 2N hydrochloric acid was added thereto, and when foaming was stopped, a saturated aqueous sodium bicarbonate solution was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was removed by evaporation, followed by purification using PLC (chloroform:methanol=10:1) to obtain 2.5 mg (yield 26%) of a title compound as a pale yellow oily substance.

Provenance & Evidence