Diethyl Ether → HCID 59323090, compound

HRID 2390047Notes

Reaction equation

HRID 2390047 reaction equation
[CH2:1]([C:8]1[N:9]([S:19]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])(=[O:21])=[O:20])[CH2:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OCC)C>C(O)C.[Pd]>[CH2:1]([CH:8]1[CH2:17][C:16]2[C:11](=[C:12]([F:18])[CH:13]=[CH:14][CH:15]=2)[CH2:10][N:9]1[S:19]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])(=[O:21])=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 3283Diethyl EtherHCID 59323043HCID 59323043, compound

Product 1

HCID 59323090HCID 59323090, compoundYield 110.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Under a hydrogen atmosphere, 9 mg of methyl 3-[(3-benzyl-8-fluoroisoquinolin-2(1H)-yl)sulfonyl]propanoate and 9 mg of 10% Pd/C were dissolved in 1 mL of ethanol, followed by stirring at room temperature for 2 hours. After completion of the reaction, to the reaction liquid was added diethyl ether, followed by filtration through Celite, and the filtrate was concentrated under reduced pressure to obtain 10 mg (yield 100%) of a title compound as a yellow oily substance.

Workup

  1. customAfter completion of the reaction
  2. customto the reaction liquid
  3. filtrationfollowed by filtration through Celite
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fcbea10ad4444fedab16383264d2641c
Source dataset
uspto-grants-2012_09
Patent number
US08273766B2

Reaction notes

Loading…