N-methoxy-N,3-dimethylbutanamide → 4-Methyl-1-(4-toluyl)-pentan-2-one

HRID 2390049Notes

Reaction equation

HRID 2390049 reaction equation
CON(C)[C:4](=[O:9])[CH2:5][CH:6]([CH3:8])[CH3:7].[CH3:11][C:12]1[CH:20]=[CH:19][C:15]([CH2:16][Mg]Cl)=[CH:14][CH:13]=1>>[CH3:7][CH:6]([CH3:8])[CH2:5][C:4](=[O:9])[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([CH3:16])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 10975620N-methoxy-N,3-dimethylbutanamideHCID 178425359HCID 178425359, compound

Product 1

HCID 392382964-Methyl-1-(4-toluyl)-pentan-2-one

Procedure

The reaction and treatment were carried out in the same manner as in Example 36-b) using N-methoxy-N-methyl-3-methylbutanamide and 4-methylbenzyl magnesium chloride to obtain a title compound as a light yellow oily substance.

Workup

  1. customThe reaction and treatment

Sources & evidence

ORD record
ord-4053eec3ed5a42c1ab2e6d09e506368a
Source dataset
uspto-grants-2012_09
Patent number
US08273766B2

Reaction notes

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